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Articles in Press

January 2018

Volume 1  Issue 1


Case Report

Periprostetic Osteolysis After 2 Level Cervical Disc Arthroplasty Featuring Artificial Nucleus

Jacob J. Ruzevick, Theodore Wagner, Christoph P. Hofstetter*

Artificial disc cervical arthroplasties are commonly performed with favorable outcomes. Here we present a rare case of Periprostetic Osteolysis in the cervical spine of a 60 year-old man who underwent placement of a C4/5 and C5/6 M6-C cervical disc arthroplasty (Spinal Kinetics, CA, USA) in 2007 in Germany. This novel implant mimics the human disc by incorporating an artificial annulus between two titanium plates. The patient did well initially but then presented 8 years after the procedure with neck and bilateral upper extremity radiculopathy.


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Research Article

High-Throughput Screening of Interaction Partners for MAGE-H1 during Retinoic Acid-Induced Neural Differentiation of P19 Cells Using SILAC-Immunoprecipitation Quantitative Proteomics Approach

Yong Liu*, Yujian Chen, Shide Lin, Haiping Que, Shuguang Yang, Shaojun Liu*

MAGE-H1 might be involved in the early process of neurogenesis. However, fundamental roles of MAGE-H1 during neurogenesis still need to be further investigated. In this study, we used Stable Isotope Labeling by Amino acids in Cell culture (SILAC) -immunoprecipitation quantitative proteomics to identify interaction partners of MAGE-H1 during retinoic acid (RA)-induced neural differentiation of P19 cells, and found that 62 proteins could specifically interact with MAGE-H1. Subsequently, we performed functional annotation of the identified proteins.

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Review Article

Wireless Dorsal Root Ganglion Stimulation for treatment of chronic pain: A Review and update on recent advances with minimally invasive Stimwave Wireless Technology

LT Perryman MS, MBA*

Therapeutic application of electrical stimulation of dorsal columns of spinal cord, known as spinal cord stimulation (SCS) has been in use since Shealy et al described in 1967 for relief of pain in terminally ill patient. SCS has its basis in gate control therapy, and acts by attenuation of pain transmission by activating the afferent A fibers. It also recruits multiple fiber tracts supplying several dermatomes and structures probably not responsible for the pain generation.

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Original peer-Review Article

Curve Progression in Children with Spinal Deformity after Removal of Vertical
Expandable Prosthetic Titanium Ribs

Andrea S. Gantner1, Lena Braunschweig2, Konstantinos Tsaknakis3, Heiko M. Lorenz4, Anna K. Hell5*

Progressive spinal deformity in children often requires early and repetitive surgical treatment. In the last decades, several growth-friendly devices such as vertical expandable prosthetic titanium rib (VEPTR) implants [1, 2], magnetically controlled devices [3, 4], growing rods [5, 6] and other growth-guided implants [7, 8] have been used to achieve this goal. However, the majority of these constructs serve as interim solutions, requiring definitive spinal fusion in puberty [9].

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